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Chemical Structure| 88738-78-7 Chemical Structure| 88738-78-7
Chemical Structure| 88738-78-7

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Methyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate is used in the synthesis of trans-hydrindanes.

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Product Details of Bis(2,2,2-trifluoroethyl) [(methoxycarbonyl)methyl]phosphonate

CAS No. :88738-78-7
Formula : C7H9F6O5P
M.W : 318.11
SMILES Code : COC(=O)CP(=O)(OCC(F)(F)F)OCC(F)(F)F
MDL No. :MFCD00009901
InChI Key :PVSJXEDBEXYLML-UHFFFAOYSA-N
Pubchem ID :184894

Safety of Bis(2,2,2-trifluoroethyl) [(methoxycarbonyl)methyl]phosphonate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Bis(2,2,2-trifluoroethyl) [(methoxycarbonyl)methyl]phosphonate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 88738-78-7 ]

[ 88738-78-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 88738-78-7 ]
  • [ 146137-79-3 ]
  • [ 310464-92-7 ]
  • 2
  • [ 17408-16-1 ]
  • [ 88738-78-7 ]
  • methyl (Z)-3-(m-nitrophenyl)-2-pentenoate [ No CAS ]
  • methyl (E)-3-(m-nitrophenyl)-2-pentenoate [ No CAS ]
  • 3
  • [ 1413945-87-5 ]
  • [ 88738-78-7 ]
  • [ 98548-81-3 ]
YieldReaction ConditionsOperation in experiment
1.09 g With lithium chloride; sodium hydroxide; In tetrahydrofuran; water; at 0 - 30℃;Inert atmosphere; Under nitrogen protection,Methyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate (3.18 g, 1 eq) was dissolved in tetrahydrofuran and lithium chloride (0.42 g, 1 eq) was added.Add sodium hydroxide in water (2.0 g, 5 eq, 1 mol/L) solution,Control temperature is 0 ° C to 30 ° C,Join again2-(Dimethylamino)acetaldehyde sulfite (3.4 g, 2 eq),Stir the reaction for 3 hours,After the reaction is completed, it is acidified,Extraction and column purification gave (2Z)-4-(dimethylamino)-2-butenoic acid hydrochloride (1.09 g).
 

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